Isotopically Labeled Compounds
Medchemexpress LLC Baclofen-d4 | 1189938-30-4 | 99.98% | C10H8D4ClNO2 | 1 MG
Baclofen-d4 | 1189938-30-4 | 99.98% | C10H8D4ClNO2 | 1 MG
![Revvity Health Sciences Inc Glucose, D-[3-3H]-, Ethanol Solution, 5 mCi (185 MBq)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/509051287.jpg-250.jpg)
Revvity Health Sciences Inc Glucose, D-[3-3H]-, Ethanol Solution, 5 mCi (185 MBq)
Glucose, D-[3-3H]-, Ethanol Solution, 5 mCi (185 MBq)
Medchemexpress LLC Tipranavir-d7 | 174484-41-4 | C31H26D7F3N2O5S | 5 MG
Tipranavir-d7 is a deuterated form of Tipranavir. Tipranavir is known to inhibit the enzymatic activity and dimerization of HIV-1 protease. It demonstrates potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates, with IC50s ranging from 66-410 nM. Additionally, Tipranavir has been shown to inhibit SARS-CoV-2 3CLpro activity.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Exerts potent activity against a wide spectrum of wild-type and multi-PI-resistant HIV-1 variants.
- Inhibits the enzymatic activity of HIV-1 protease.
- Blocks the dimerization of protease subunits.
Medchemexpress LLC Glyburide-d3 | 1219803-02-7 | C23H25D3ClN3O5S | 5 MG
Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor used for diabetes and obesity research. It inhibits P-glycoprotein, directly binds and blocks the SUR1 subunits of KATP, and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). It interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability and can induce autophagy.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Inhibits P-glycoprotein.
- Blocks SUR1 subunits of KATP.
- Inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR).
- Interferes with mitochondrial bioenergetics.
- Induces autophagy.
Medchemexpress LLC Roflumilast-d4 N-Oxide | 1794760-31-8 | C17H10D4Cl2F2N2O4 | 1 MG
Roflumilast-d4 N-Oxide is a deuterium-labeled form of Roflumilast, which is a selective PDE4 inhibitor. It exhibits IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3, or PDE5 isoenzymes from various cells.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process
- Deuteration is notable for its potential to impact the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Monomethyl auristatin E-d8 | 2070009-72-0 | C₃₉H₅₉D₈N₅O₇ | 5 MG
Monomethyl auristatin E-d8 (MMAE-d8) is a deuterated labeled monomethyl auristatin E, functioning as a potent mitotic inhibitor and tubulin inhibitor. It is utilized in antibody-drug conjugates (ADC) as a cytotoxic payload and can serve as a tracer or internal standard for quantitative analysis.
- Potent mitotic and tubulin inhibitor
- Used in antibody-drug conjugates (ADC) as a cytotoxic payload
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Targets microtubule/tubulin and ADC cytotoxins
- Relevant to cell cycle/DNA damage, cytoskeleton, and antibody-drug conjugate related research
Cayman Chemical SulfadIazIn-d4 1mg
An internal standard for the quantification of sulfadiazine by GC- or LC-MS
Medchemexpress LLC Prostaglandin E2-d4 | 34210-10-1 | 99.9% | 356.49 | C20H28D4O5 | 50 UG
Prostaglandin E2-d4 is a deuterium-labeled analogue of prostaglandin E2 used as an internal standard for quantitative analytical assays. It is provided as a 1.40 mM solution (100 μL, 50 μg) in methyl acetate, appears as a colorless to light yellow liquid, and is intended for research use with storage at -20°C.
- Deuterium-labeled internal standard for accurate quantitation.
- High purity (99.9%) for reliable analytical results.
- Ready-to-use solution (1.40 mM in methyl acetate) for convenience.
- Compatible with LC-MS/MS and other mass spectrometry methods.
- Stable when stored at -20°C for up to 2 years.
Medchemexpress LLC Adipic acid-d10 | 25373-21-1 | MFCD00190459 | 99.9% | 156.20 g·mol⁻¹ | C6D10O4 | 100 MG
Adipic acid-d10 is the deuterium-labeled analogue of adipic acid (C6D10O4, MW 156.20 g·mol⁻¹; CAS 25373-21-1) formulated for use as a tracer and internal standard in quantitative analytical workflows. It provides consistent isotopic enrichment and high chemical purity to support accurate identification and reliable quantitation in NMR, GC-MS, and LC-MS applications.
- High chemical purity suitable for analytical applications.
- Consistent isotopic labeling for reliable internal standard performance.
- Compatible with NMR, GC-MS, and LC-MS workflows.
- Available in small package sizes for laboratory use.
- Facilitates accurate quantitation and peak identification.
- Stable under typical storage conditions for labeled standards.
Medchemexpress LLC Diphenylsulfane-d1 | 180802-01-1 | 99.5% | 196.33 | C12D10S | 50 MG
Diphenylsulfane-d1 is the deuterium-labeled analogue of diphenylsulfane, provided for use as a stable isotope reference standard and for tracer applications in research and analytical workflows. The product is characterized by formula C12D10S, molecular weight 196.33, and is supplied with batch-specific analytical documentation.
Cayman Chemical LornoxIcam-d4 1mg
An internal standard for the quantification of lornoxicam by GC- or LC-MS
Medchemexpress LLC Cysteamine-d4 hydrochloride | 1219805-04-5 | 95.1% | C2H4D4ClNS | 1 MG
Cysteamine-d4 hydrochloride is a deuterium-labeled form of Cysteamine hydrochloride. Cysteamine hydrochloride is an orally active agent used in the treatment of nephropathic cystinosis and as an antioxidant. This compound serves as a tracer and an internal standard for quantitative analysis, leveraging the potential of deuteration to influence pharmacokinetic and metabolic profiles.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may affect pharmacokinetic and metabolic profiles of drugs
- Orally active for nephropathic cystinosis treatment
- Acts as an antioxidant
Cambridge Isotope Laboratories cis-Nonachlor (unlabeled) 100 ug/mL in nonane 1 2 mL
cis-Nonachlor (unlabeled) 100 ug/mL in nonane 1 2 mL
Cambridge Isotope Laboratories BROMOACETIC ACID (2-13C, 99%), 5 G, 64891-77-6
BROMOACETIC ACID (2-13C, 99%), 5 G, 64891-77-6